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In one case, I went as far as a two and a half year fight in Federal court. But the bulk of my time has been wasted sending DMCA notices to sites that take down one infringement only to put up another.
After years of frustration I had given up even trying, but when copyright infringements began appearing above my own pages in Google search following their 2011 Panda update, fighting infringements took on a new urgency. I've probably spent more time fighting copyright infringements than writing books over the last six years.